hrp0084p2-577 | Thyroid | ESPE2015

Osteoprotegerin and fT4 Levels in Subclinical Hypothyroidism of Childhood

Giannakopoulos Aristeidis , Katsantoni Elena , Efthymiadou Alexandra , Kritikou Dimitra , Chrysis Dionisios

Background: Osteoprotegerin (OPG) is a cytokine of the tumour necrosis factor receptor family, expressed in various cells types of the body including osteoblasts and endothelial cells. It acts as a soluble decoy receptor of RANK ligand preventing stimulation of osteoclastogenesis. In adults, subclinical hypothyroidism (SH) has been associated with cardiovascular complications. Furthermore several studies have linked OPG levels to increased cardiovascular risk.<p class="abs...